Lifecycle information for e-literature: full report from the LIFE project

This Report is a record of the LIFE Project. The Project has been run for one year and its aim is to deliver crucial information about the cost and management of digital material. This information should then in turn be able to be applied to any institution that has an interest in preserving and providing access to electronic collections. The Project is a joint venture between The British Library and UCL Library Services. The Project is funded by JISC under programme area (i) as listed in paragraph 16 of the JISC 4/04 circular- Institutional Management Support and Collaboration and as such has set requirements and outcomes which must be met and the Project has done its best to do so. Where the Project has been unable to answer specific questions, strong recommendations have been made for future Project work to do so. The outcomes of this Project are expected to be a practical set of guidelines and a framework within which costs can be applied to digital collections in order to answer the following questions: • What is the long term cost of preserving digital material; • Who is going to do it; • What are the long term costs for a library in HE/FE to partner with another institution to carry out long term archiving; • What are the comparative long-term costs of a paper and digital copy of the same publication; • At what point will there be sufficient confidence in the stability and maturity of digital preservation to switch from paper for publications available in parallel formats; • What are the relative risks of digital versus paper archiving. The Project has attempted to answer these questions by using a developing lifecycle methodology and three diverse collections of digital content. The LIFE Project team chose UCL e-journals, BL Web Archiving and the BL VDEP digital collections to provide a strong challenge to the methodology as well as to help reach the key Project aim of attributing long term cost to digital collections. The results from the Case Studies and the Project findings are both surprising and illuminating

Lifecycle information for e-literature: a summary from the LIFE project.

The LIFE Project has developed a methodology to calculate the long-term costs and future requirements of the preservation of digital assets. LIFE has achieved this by analysing and comparing three different digital collections and by applying a lifecycle approach to each. From this work LIFE has identified a number of strategic issues and common needs. The critical strategic issues are: •There is a need for a wider collaborative approach between Higher Education (HE) and Libraries to aid in the cost-effective development of tools and methods. •The time required for the realistic development of the next generation of these tools and methodologies is largely unknown and should form part of a collective responsibility within the digital preservation community. •There exists a real opportunity to establish long-term partnerships between institutions to address common requirements. The challenge is to establish multidisciplinary Project teams and programmes to lead these developments. •There exists a real opportunity to establish long-term partnerships between institutions and industry to develop this methodology and to establish new opportunities to share knowledge and experience. The LIFE project could become an important vehicle for the development of these new opportunities

Spectroscopic observations of the eclipsing Polar MN Hya (RX J0929--24)

We present low--medium resolution optical spectroscopy of the eclipsing AM Her system MN Hya (RX J0929--24). We determine the magnetic field strength at the primary accretion region of the white dwarf to be 42MG from the spacing of cyclotron features visible during ~0.4--0.7. From spectra taken during the eclipse we find that the secondary has a M3--4 spectral type. Combined with the eclipse photometry of Sekiguchi, Nakada & Bassett and an estimate of the interstellar extinction we find a distance of ~300--700pc. We find unusual line variations at phase ~0.9: Halpha is seen in absorption and emission. This is at the same point in the orbital phase that a prominent absorption dip is seen in soft X-rays.Comment: accepted by MNRAS, 7 pages, 5 fig

LIFE3: A predictive costing tool for digital collections

Predicting the costs of long-term digital preservation is a crucial yet complex task for even the largest repositories and institutions. For smaller projects and individual researchers faced with preservation requirements, the problem is even more overwhelming, as they lack the accumulated experience of the former. Yet being able to estimate future preservation costs is vital to answering a range of important questions for each. The LIFE (Life Cycle Information for E-Literature) project, which has just completed its third phase, helps institutions and researchers address these concerns, reducing the financial and preservation risks, and allowing decision makers to assess a range of options in order to achieve effective preservation while operating within financial restraints. The project is a collaboration between University College London (UCL), The British Library and the Humanities Advanced Technology and Information Institute (HATII) at the University of Glasgow. Funding has been supplied in the UK by the Joint Information Systems Committee (JISC) and the Research Information Network (RIN)

Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity

Survivin is an essential chromosomal passenger protein required for mitotic progression. It is also an inhibitor of apoptosis and can prevent caspase-mediated cell death. In addition, survivin levels are elevated in cancer cells where its presence correlates with increased resistance to chemo- and radio-therapy, which makes it an attractive target for novel anti-cancer strategies. Interestingly, survivin is phosphorylated by the mitotic kinase, cdk1, and a non-phosphorylatable form, survivin(T34A), cannot inhibit apoptosis. Here we rigorously test the ability of survivin(T34A) and its corresponding phosphomimetic, survivin(T34E), to promote cell viability through survivin's dual roles. The effects of these mutations are diametrically opposed: survivin(T34A) accelerates cell proliferation and promotes apoptosis, whereas survivin(T34E) retards growth and promotes survival. Thus the phosphorylation status of survivin at T34 is pivotal to a cell's decision to live or die

How much does it cost? The LIFE Project - costing models for digital curation and preservation

Digital preservation is concerned with the long-term safekeeping of electronic resources. How can we be confident of their permanence, if we do not know the cost of preservation? The LIFE (Lifecycle Information for E-Literature) Project has made a major step forward in understanding the long-term costs in this complex area. The LIFE Project has developed a methodology to model the digital lifecycle and to calculate the costs of preserving digital information for the next 5, 10 or 100 years. National and higher education (HE) libraries can now apply this process and plan effectively for the preservation of their digital collections. Based on previous work undertaken on the lifecycles of paper-based materials, the LIFE Project created a lifecycle model and applied it to real-life digital collections across a diverse subject range. Three case studies examined the everyday operations, processes and costs involved in their respective activities. The results were then used to calculate the direct costs for each element of the digital lifecycle. The Project has made major advances in costing preservation activities, as well as making detailed costs of real digital preservation activities available. The second phase of LIFE (LIFE2), which recently started, aims to refine the lifecycle methodology and to add a greater range and breadth to the project with additional exemplar case studies

The LIFE Model v1.1

Extract: This document draws together feedback, discussion and review of the LIFE Model from a number of sources: 1. The LIFE and LIFE2 Project Teams, and the staff of their institutions 2. Feedback from review by independent economics expert 3. The LIFE Project Conference 4. Early adopters of the Life Model (particularly the Royal Danish Library, State Archives and the State and University Library, Denmark) The result is a revision of the LIFE Model which was first published in 2006 by the LIFE Project . In line with the objectives of the LIFE2 Project, this revision aims to: 1. fix outstanding anomalies or omissions in the Model 2. scope and define the Model and its components more precisely 3. facilitate useful and repeatable mapping and costing of digital lifecycles

One-dimensional search combining golden section and cubic fit techniques Quarterly report

One dimensional search routine for function of one variable and approximation of function with cubic equatio

Transporting cells over several days without dry-ice

This paper describes a simple, hazard-free and inexpensive procedure that allows researchers to send cultured cells across the globe at ambient temperatures. The method enables transit of up to 2 weeks without compromising cell recovery. Its use will assist collaborators in distant laboratories to exchange cells without using dry-ice